Depression during pregnancy may lead to preterm delivery

Pregnancy is supposed to be one of the happiest times of a woman’s life, but for many women this is a time of confusion, fear, sadness, stress, and even depression. About 10-20% of women will struggle with some symptoms of depression during pregnancy, and a quarter to half of these will suffer from major depression.

Depression is a mood disorder that affects 1 in 4 women at some point during their lifetime, so it should be no surprise that this illness would also touch women who are pregnant. But all too often, depression is not diagnosed properly during pregnancy because people think it is just another type of hormonal imbalance. This assumption can be dangerous for the mother and the unborn baby.

Women who are depressed early in their pregnancy run a higher risk of preterm delivery, the leading cause of infant mortality, a new study suggests.

For the study, researchers interviewed 791 San Francisco-area women near their 10th week of pregnancy. Forty-one percent reported “significant” symptoms of depression, and 22 percent reported “severe” symptoms.

Those women with severe symptoms had almost twice the risk of an early birth, defined as before 37 weeks’ gestation. Those with significant symptoms had a 60 percent risk of early birth, the study found.

Women who were likelier to report depressive symptoms tended to be younger than 25, unmarried, less educated, poorer, black, and have a history of preterm delivery.

Discovering a possible cause of preterm birth, about which little is known, makes the findings significant, said study lead author Dr. De-Kun Li, a perinatal epidemiologist and senior research scientist at Kaiser Permanente’s Division of Research in Oakland, Calif.

Scientists have been researching for the causes of high rates of infant mortality in the United States, Li said, but, “we don’t know what is going on. If we can find something as obvious as depression that can be treated during pregnancy, that is very, very significant.”

The findings were published online Oct. 23 in the journal Human Reproduction.

Dr. Shari I. Lusskin, director of reproductive psychiatry at New York University Medical Center, said she doesn’t think the study establishes a link between depression in early pregnancy and preterm delivery. She said the women in the study weren’t clinically diagnosed with depression but had scored high on a screening test.

“We don’t know if the depression at 10 weeks is a marker for something that happens later in pregnancy, which is the real culprit,” she said.

Li hopes the study’s findings will make “ante-natal depression” as widely recognized as postpartum depression has become. Until now, depression during pregnancy has been “under-estimated and under-treated,” he said, “not just by women, but also by their doctors.”

One reason for this lack of attention is that there hasn’t been strong evidence of a connection between depression in pregnant women and harm to the fetus, Li said.

Women may not readily report depressed feelings when they are pregnant because of the societal expectation that having a baby should be a joyous occasion, said Dr. Jennifer Wu, an obstetrician and gynecologist at Lenox Hill Hospital in New York City.

“I think many patients are very stressed about pregnancy and worried about the pregnancy and not sure about its impact on their lives,” Wu said.

Lusskin tries to spread the word about the dangers of depression during pregnancy.

“The more we know about postpartum depression, the more we realize that half the cases started in pregnancy,” Lusskin said. Ante-natal depression also carries the risk of noncompliance with prenatal care, poor nutrition, inadequate sleep, self-medication with drugs and alcohol, and suicide, she explained.

And, Lusskin added, “Ante-natal depression interferes with bonding with the baby both during pregnancy and post-partum.”

The take-home lesson from the Kaiser study, Lusskin said, “is that ante-natal depression and ante-natal depression symptoms have some effect on pregnancy, and they should be treated, even though we don’t know how that mood is translated into the biochemistry of that pregnancy.”

What is the treatment for depression during pregnancy?

If you feel you may be struggling with depression, the most important thing is to seek help. Talk with your health care provider about your symptoms and struggles. Your health care provider wants the healthiest choice for you and your baby and may discuss options with you for treatment. Treatment options for women who are pregnant can include:

1. Support groups

2.   Private psychotherapy

3.   Medication

4.   Light therapy

If your symptoms are severe, your health care provider may want to prescribe medication immediately. There are medications that have been used during pregnancy without adverse affects. Discuss with your health care provider what he/she feels is safest for your baby but still beneficial to you.

If you do not feel comfortable talking with your health care provider about your feelings of depression, find someone else to talk with. The most important thing is that someone knows what you are dealing with and can try to help you. Never try to face depression alone. Your baby needs you to seek help and get treatment.


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