Tag Archives: Egg Freezing

ESHRE Endorses Egg Freezing : ASRM Lifts Experimental Label From Egg Freezing

The American Society of Reproductive Medicine (ASRM) and the European Society of Human Reproduction and Embryology (ESHRE) have endorsed oocyte freezing as a standard and safe procedure in  2012. ASRM  issued a new report on 22 October, 2012 stating that in young patients egg freezing techniques have been shown to produce pregnancy rates, leading to the birth of healthy babies, comparable to IVF cycles using fresh eggs. After much work and deliberation by fertility experts, who reviewed the world literature on the effectiveness and safety of egg freezing and, most importantly, on the desired outcome: healthy babies, egg freezing is can now be used in routine practice. More studies are being published regarding this age range, and all is reassuring.



Egg freezing could provide a viable alternative source for couples needing donor eggs to build their families. In addition, among the medical indications for its use are fertility preservation for patients who may be left infertile following medical treatments for other diseases  (viz., cancer),  some genetic conditions, or IVF treatment interrupted by the unexpected inability to obtain sperm.Cryotec



The Committee points out that the age of the woman at the time of egg freezing is a very important factor. “Success rates with oocyte cryopreservation appear to decline with maternal age consistent with the clinical experience with fresh oocytes.”  ASRM did not encourage egg freezing for “social reasons,” such as a delay in childbearing as, although the technical procedure of egg freezing is safe, we do not have enough long-term data about babies born to women using eggs frozen when they are older than 35. Cryotec VitrificationCiting a lack of data on safety, efficacy, cost-effectiveness, and potential emotional risks, the report states, “Marketing this technology for the purpose of deferring childbearing may give women false hope and encourage women to delay childbearing. Patients who wish to pursue this technology should be carefully counseled.”



Rotunda is now offering oocyte cryopreservation as part of its ART services  using the latest cutting edge Cryotec vitrification technique. We also have initiated donor egg bank. We have achieved comparable success rates with frozen donor oocytes  to fresh donor oocytes.

Rotunda Egg Freezing ProgramThe excellent survival rates, embryo development and pregnancy rates have given a tremendous new hope to young cancer women. These young cancer patients can now dream of becoming a mother one day in future when they are cured of their disease.


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Lord Winston, Labels Egg Feezing As “Expensive Confidence

Lord Winston, emeritus Professor of Fertility Studies at Imperial College London and pioneer of IVF, has criticized fertility clinics for over-hyping egg freezing services. In an interview with the Daily Mail newspaper he accuses providers of creating false optimism in the effectiveness of the procedure particularly where signing up patients for purely ‘social’ reasons. Before use of egg freezing grows further he calls for more research into both the effects of egg freezing on the ability to later conceive and into the long-term health implications for those born
from frozen eggs.
The comments come in response to calls, made at last week’s European Society for Human Reproduction and Embryology (ESHRE) annual conference, for greater availability of egg freezing as an option for women who are postponing pregnancy until later in their lives. Lord Winston’s comments partially mirror a joint statement made in February by the UK’s Royal College of Obstetricians and Gynaecologists and the British Fertility
Society (BFS) which also called for women not to freeze eggs for social reasons.
Lord Winston noted that the production of six to ten eggs for freezing involves both the risk of ovarian hyperstimulation syndrome for the woman and an increased likelihood of chromosome defects in the eggs produced. Producing such a quantity of eggs he sees as dangerous yet also inadequate to ensure a viable embryo is produced. The BFS has stated that the average chance of success for any individual frozen egg is six per cent and only four children have been born from frozen eggs in the UK to date.
Additionally, the lack of data on the long term health effects – the first children conceived with frozen eggs are only now five – is provided as reason enough for adopting a cautious approach towards increasing availability of egg freezing and makes encouraging those without a pressing need (such as impending cancer treatment) all the more dubious. Lord Winston states, in unequivocal terms, ‘in my view it is irresponsible [for clinics] to egg freeze until long-term animal research has been done’. The most detailed research to date is due to be published next month.
Describing the procedure as a ‘quick fix’, Lord Winston sees the best path forward for prolonging the ability to have a child, for social reasons, is to attempt to develop better means of postponing the menopause. Though the procedure can be justified for those with serious medical conditions it is not be encouraged as a means of delaying motherhood. The provision of egg freezing for social reasons, available for between £2,500 and £5,000 at 45 clinics in the UK, is in his view simply an ‘undesirable commercial activity’ and should not be encouraged.

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Study Shows It May Be Possible to Preserve Child-Bearing Ability in Young Girls with Cancer

Research appearing in the on-line edition of Fertility and Sterility revealed that it may be possible for girls suffering from cancer in childhood to preserve their ability to have children later in life.

While advances in cancer therapies have dramatically improved survival rates for patients who suffer from childhood cancers, the use of chemotherapy and radiation often results in impaired fertility or sterility as those patients reach adulthood. For males mature enough to be producing sperm, sperm freezing has long been an option. For young females however, the ovulation induction and egg freezing techniques that might help adult women are not an option.

Researchers at Hadassah Hebrew University Medical Center in Jerusalem examined the ability to remove and preserve ovarian tissue from young female cancer patients and then retrieve, mature and freeze eggs from that tissue. They worked with 19 patients between the ages of 5 and 20. On average they were able to retrieve an average of nine oocytes per patient and 34% of them were successfully matured. The next step in this research will be test the ability of these eggs to become fertilized.

“As our ability to treat childhood cancers improves, it becomes more important that those survivors are able to live rich, full lives, including the ability have children. This research helps moves us to the goal of allowing pediatric cancer survivors to become parents,” said David Adamson, MD, President of the American Society for Reproductive Medicine.

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Mother freezes her own eggs to give her daughter the chance of having a baby

A mother whose young daughter will never be able to conceive naturally has frozen her own eggs to give the girl a chance of starting a family when she grows up.

The girl, aged ten, was born with a rare genetic condition which means she is infertile. Her mother had several eggs frozen in 2005 which could be used by her daughter for IVF treatment. Under the procedure, which is legal and has been approved by Government ethics committees, the girl could use her mother’s eggs to give birth to her own half-sister or half-brother. But legislation limiting the amount of time eggs can be frozen means Mollie – not her real name – will have to decide before her 18th birthday whether to use the eggs.

They were harvested from her mother in 2005 when Mollie was seven. They can be stored for a maximum of ten years, so she will be only 17 when the time limit expires. If she does not use them by the end of 2015 then, by law, all the eggs would have to be destroyed. The Human Fertilisation and Embryology Authority does allow for the ten-year limit to be extended, but only if the eggs are intended for the donor’s own treatment.

Now Mollie’s mother is campaigning for a reform in the law which would give her daughter more time to make the life-changing decision. The mother, from Hazel Grove, Stockport, said: ‘We only want to give Mollie the same chances as everyone else to have a child of her own. ‘I don’t want to put my daughter under pressure and I don’t think she should be having to make that choice at that age.

‘We feel real sadness that for no particularly justifiable reason our daughter is going to be put in an impossible situation.’

Mollie has Turner’s syndrome, a chromosome abnormality which affects around one in 2,500 girls born every year. The condition causes growth problems, heart defects and physical abnormalities including infertility, a higher risk of diabetes, and ear and urinary infections. The eggs, which are stored in liquid nitrogen at minus 196 degrees Celcius, do not deteriorate and can be stored indefinitely because they are in a state of suspended animation at the temperature-at which all cellular activity ceases.

Mollie’s mother said: ‘She already knows that she is different. We have tried to keep her as informed as we can. ‘We have talked to her about how when she has children it might be different. We just want our daughter to have the same chances as our son.

‘People might think there is something strange about it but really it is no different from people who donate to their sisters.

‘It is to ensure the closest possible genetic match. It has been considered by ethics committees and they have no objection to it.’

Embryology rules state that only women under the age of 36 can freeze eggs because after that the risk of birth defects increases. At least half a dozen British mothers have frozen their eggs to allow their infertile daughters to conceive at a later date.

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