Children For Wombless Women – The MRKH Syndrome

Mr. and Mrs. XYZ first approached our clinic with their problem of Primary Infertility on 31st January 2005. The couple has been married for the past two and a half years and came to us asking for IVF with gestational surrogacy. Mrs XYZ, 30 years of age, was aware that she had a rare a congenital uterine abnormality called Mayer- Rokitansky Kustner Hauser Syndrome. Patients with MRKH syndrome have failed development of the embryonic Mullerian ducts. They have absolutely normal secondary sexual characteristics like breast development etc. Normal development of these ducts result in the formation of the uterus, cervix and the upper 2/3 of the vagina. However, failure of the same results in a variety of abnormalities, most common being vaginal atresia and agenesis of the uterus and cervix. There is however normal ovarian development and normal ovarian function.

A preliminary examination and a basic hormonal screening test were done to rule out other hormonal imbalances. The patient was then advised to keep a Basal Body Temperature chart for a month to confirm the dates of ovulation to help us plan a cycle. As soon as a we localized her cycle dates, her treatment cycle was begun and synchronized with the surrogate’s cycle. She was given gonadotropin injections to stimulate her ovaries to produce multiple mature eggs. A laparoscopic Ovum pick-up was scheduled as her ovaries high in the pelvis making vaginal ovum pick-up difficult. We managed to obtain just three mature eggs which were then fertilized with her husband’s sperms and finally two embryos were transferred into the surrogate on day 2 but her pregnancy test came negative.

The patient, however, did not lose hope and decided to do another treatment cycle. We started the cycle again with a little more ovarian stimulation with fertility injections to get more eggs. The surrogate was also started on hormonal replacement therapy to prepare her uterine lining. This time we managed to obtain 10 eggs of which 9 fertilized and we transferred four embryos. The surrogate got pregnant and subsequently delivered full term twins . The treatment has fulfilled the hopes and dreams of this woman who was born without a womb. We have now successfully treated three other women with MRKH syndrome to complete their families. God Bless!

16 responses to “Children For Wombless Women – The MRKH Syndrome

  1. I would like to know, the address & contact no. of above surrogacy !! I would like to go for the same !! It gives me hopes.

    Thanks & Regards,

  2. Mike Buonaiuto

    hello – this is a very interesting post – i have just finished producing a short documentary on surrogacy here in the uk – it covers the changes in laws which are occuring – and the problems some people can face when going through the process to overcome infertility – it can be found on my blog – – and – feel free to have a look – it would be great if you could get back to me with any comments and debate – thanks – mike

  3. wow this looks interesting..i now have no womb due to cervical cancer,. i have a 7 year old and had given up finding a way to give him a brother or sister,. or both. im certainly going to look into this further..wish me aussie girl…ps just gotta talk my hubby into it… cross my fingers and toes..

  4. Rose

    I have MRKH, and this post gives me hope. I am talking seriously about marriage now and the reality of my condition has been weighing on me. Thank you for sharing this success story.

  5. Pingback: Children for Wombless Women. « MRKH Canada Blog

  6. sofia butt

    I also lost my Uterus because of Cancer and now we want to proceed with rotunda clinic to help us making a baby by putting our things into a surrogate. In Sweden the procedure is illegal so far. But the laws are changing and maybe in a 10 year period this will be ok for sweden as well. Hopful for a successful pregnancy in may 🙂 // Sofia

  7. Mr A. U. Ogborho

    It is really a good thing to have gone that far to discover a method of treatment that has given & will still continue to give joy to millions of people out there.i really appreciate your concern for human life,may god bless you.though i am an undergraduate in psychology dept but i would like to learn more so as to equip myself of more knowledge because my dream is to be a clinical psychologist.

  8. Meredith Feira

    I was diagnosed with MRKH when I was 15 years old. I am now 20 years old and married to a great guy who fully supports my wish to have a gestational surrogate carry our child one day. We are now talking seriously about starting the process soon, and this article has really been uplifting. 🙂

    • Dayana Chavez

      I was diagnosed when I was 16!. I have never met someone that has MRKH. I was just wondering if anyone would like to talk to me, my email is . I am just curious and probably will share the same questions you always had in your mind. Has anyone heard of someone that has a baby without a surrogate mother? A.k.a. c section?

  9. deepak

    It gives me and my wife a hope that we can have a baby. Please give me address. I am eargly waiting. Pls pls.

  10. subhashini

    i were born with Mrkh syndrome. i got married. i would like to get this contact number i lives in chennai.

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